BackgroundBeta thalassemia major is a severe inherited form of hemolytic anemia that results from ineffective erythropoiesis. Allogenic hematopoietic stem cell transplantation (HSCT) remains the only potentially curative therapy. Unfortunately, the subgroup of adult thalassemia patients with hepatomegaly, portal fibrosis and a history of irregular iron chelation have an elevated risk for transplantation-related mortality that is currently estimated to be about 29 percent.DiscussionThalassemia patients may be faced with a difficult choice: they can either continue conventional transfusion and iron chelation therapy or (...) accept the high mortality risk of HSCT in the hope of obtaining complete recovery.Throughout the decision making process, every effort should be made to sustain and enhance autonomous choice. The concept of conscious consent becomes particularly important. The patient must be made fully aware of the favourable and adverse outcomes of HSCT. Although it is the physician's duty to illustrate the possibility of completely restoring health, considerable emphasis should be put on the adverse effects of the procedure. The physician also needs to decide whether the patient is eligible for HSCT according to the "rule of descending order". The patient must be given full details on self-care and fundamental lifestyle changes and be fully aware that he/she will be partly responsible for the outcome.SummaryOnly if all the aforesaid conditions are satisfied can it be considered reasonable to propose unrelated HSCT as a potential cure for high risk thalassemia patients. (shrink)

The informed consent process is the legal embodiment of the fundamental right of the individual to make decisions affecting his or her health., and the patient’s permission is a crucial form of respect of freedom and dignity, it becomes extremely important to enhance the patient’s understanding and recall of the information given by the physician. This statement acquires additional weight when the medical treatment proposed can potentially be detrimental or even fatal. This is the case of thalassemia patients pertaining to (...) class 3 of the Pesaro classification where Allogenic hematopoietic stem cell transplantation remains the only potentially curative treatment. Unfortunately, this kind of intervention is burdened by an elevated transplantation-related mortality risk , equal to 30% according to published reports. In thalassemia, the role of the patient in the informed consent process leading up to HSCT has not been fully investigated. This study investigated the hypothesis that information provided by physicians in the medical scenario of HSCT is not fully understood by patients and that misunderstanding and communication biases may affect the clinical decision-making process. (shrink)

Semblanza de G. Tagliacozzo a través de las distintas voces que, desde su infancia hasta su muerte, lo llamaron en su vida: las primeras vocaciones de grandeza , las voces de la academia , la voz de América , la impelente voz de Vico , la voz de los caminos que la naturaleza recorre .Semblance of G. Tagliacozzo through the voices that he followed from his younger age to his death: the first calls for greatness , the voices of academy (...) , the voice of America , the impelling voice of Vico , and the voice of the ways that nature runs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Image and SilenceGiorgio AgambenTranslated by Leland de la Durantaye (bio)[End Page 94]In the Roman pantheon there is a goddess named Angerona, represented with her mouth bound and sealed (ore obligato signatoque).1 Her finger is raised to her lips as if to command silence. Scholars claim that she represents, in the context of pagan mystery cults, the power of silence, although there is no consensus among them as to how (...) to understand this power. Etymologically speaking, myein, the root of the Greek word mysterion, means “to close the mouth, to silence.” At the beginning of the sacred rites in Eleusis a herald “commanded silence” (epittatei tēn siōpen). It is said that that the initiates into these Eleusinian mysteries were required to maintain absolute silence concerning what they had seen and heard during their initiation. Our question is how to understand this silence. Was it a prohibition aimed at keeping a secret doctrine from the uninitiated? Or did it concern, instead, something truly impossible to say?To begin we might ask what sense there might have been in the obligation to remain silent given that it was possible for anyone—including slaves, and thus, potentially, the entire population of Athens—to be initiated into the mysteries. In his early work, “On Philosophy,” Aristotle affirmed that, “the initiates do not need to learn something (mathein ti), but, instead, to be disposed to something, to experience and to undergo something (pathein kai diatethēnai).”2 It would therefore be possible that in the ancient mystery cults the initiate did not learn a doctrine that could be expressed in words (yet had to remain secret), but, instead, experienced something essentially silent, something impossible to say. “A great awe in face of the gods,” we read in the Homeric ode to Demeter, “silences the voice.”3The impossibility of speaking—and the power of silence—has two forms, one joyful and the other disturbing. In myth muteness is often associated with rape. The Romans tell the story of Lara who was punished for her inclination to gossip by being rendered mute and who was then raped in a sacred wood by Mercury (who took advantage of her impossibility of speaking). Before being transformed into a swallow Philomela was raped by Tereus, who cut off her tongue to prevent her from recounting his misdeed. Persephone, raped, kidnapped, and conducted to Hades, remained there silent as the dead. In every one of these cases silence is the painful experience of a privation of speech, of being unable to say what one wishes to say.In Gnostic mythology, the preexisting, eternal, uncreated God contains within himself a female figure which is his silence, Sigē. From his union with Silence Thought is born. “Sigē,” we read in a Valentinian text, “is the mother of all the beings that have emerged from the Abyss. He who has failed to say the unsayable has silenced it; he who was understood the unsayable, has declared it unsayable.”4 Here too silence appears as the experience of an impossibility of saying, as a privation. It is in opposition to this abyssal figure of silence that the church fathers affirmed the primacy of the logos in which God is revealed. Nevertheless, of the power of silence Heidegger would write: “This primordial silence is more powerful than any human potentiality. No one, on his or her own, has ever invented language—that is, has been strong enough to break the power of this silence.”5 [End Page 95]In Kafka’s parable on Ulysses, we are told that the silence of the Sirens is more perilous than their song, and that Ulysses—who realized, as his ship neared them, that the Sirens were silent—put on an act to protect himself from this silence, plugging his ears with wax and having his men tie him to the mast.6 In Kafka’s retelling of the tale, the silence of the Sirens represents a zero degree of song and, following a stubborn tradition that sees in absence the most extreme form of presence, also represents an at once zero and ultimate degree of reality. In this sense Heidegger could write... (shrink)

Recent literature highlights that the use of smartphones during meals increases the number of calories ingested in young people. Although the distraction interferes with physiological signals of hunger and satiety, a social facilitation effect has also been suggested. Cognition is a pivotal component in regulating food intake, and activities requiring high perceptual demands should be discouraged during meals.

La ricerca può essere effettuata anche con parole non complete. Per esempio - per la ricerca dell'autore 'Gerardus van der Leeuw' può bastare l'inserimento della parola 'lee' o di altre parti del nome o del cognome. Questa possibilità facilita la ricerca di parole difficili o di cui non è semplice memorizzare la trascrizione. Se invece si inserisce nella ricerca, oltre al cognome dell'autore, anche il nome ed il titolo del libro, o almeno alcune parole significative del titolo, il risultato della (...) ricerca sarà più selettivo. (shrink)

Reseña de las sesiones de las Jornadas de estudio en torno a las ediciones y traducciones de las obras de Vico, celebradas en Nápoles con ocasión del 250º aniversario de su muerte, bajo el título general: L'edizione critica di Vico: bilanci e prospettive.Review of the sessions devoted to the study of Vico’s Work editions and translations, which tock place in Naples in commemoration of the 250th anniversary of his death, under the generai title: L'edizione critica di Vico: bilanci e prospettive.

Les trois études rassemblent des réflexions du philosophe sur trois problèmes de méthode spécifiques : le concept de paradigme, la théorie des signatures et la relation entre histoire et archéologie.

La prima parte del saggio è apparsa in «Documenti e Studi» 3, 1 271-304. L'esame analitico condotto su ciascuna delle sette questioni egidiane permette all'A. di valutare «le dimensioni e le modalità dell'impiego delle opere di Tommaso d'Aquino compiuto da Egidio Romano». Di ciascuna questione viene quindi presentata una scheda ragionata articolata in tre parti: 1) collocazione della questione ; 2) analisi delle sezioni ; 3) raffronto complessivo tra la questione studiata e l'articolo parallelo del commento al II libro Sententiarum (...) di Egidio, seguito da una valutazione generale del rapporto tra la questione di Egidio e la trattazione svolta da Tommaso. (shrink)

1. Dioniso, Apollo, Eleusi, Orfeo, Museo, Iperborei, Enigma -- 2. Epimenide, Ferecide, Talete, Anassimandro, Annassimene, Onomacrito (2. ed., 1994) -- 3. Eraclito (2a ed., 1982).

Como continuación de su artículo "My Vichian Journey: A Chronology", el autor ofrece ahora una introducción a la ciencia por él concebida: la "Dendrognoseología". Esta ciencia, cuyo principal referente es la "Ciencia Nueva" de Vico, prosigue la inmemorial preocupación humana y erudita por la unidad del conocimiento. No se trata, sin embargo, de otra concepción especulativa, sino de una ciencia; siendo ¿merced a su batería de principios única y constante¿ una estructura histórico-taxonómica independiente de toda visión del mundo, la "Dendrognoseología" (...) aparece como un prototipo válido a lo largo de toda circunstancia y tiempo que acompaña y unifica todo conocimiento en un árbol. Esta ciencia, cuyo gozne es el concepto de simbolismo (en el árbol de 1959) o el de imaginación (en el árbol viquianizado de 1989), dos elementales conceptos que son los respectivos puntos de partida de la filosofía de Cassirer y de Vico, puede ayudar a la perfección de un número indefinido de tareas tanto intelectuales como para-intelectuales. Una "Presentación" a cargo de J. M. Sevilla ¿al comienzo¿ y unas "Anotaciones" de F. Ratto ¿al final acompañan¿ a esta obra póstuma de Giorgio Tagliacozzo, que ha sido publicada en español (Tagliacozzo preparó y revisó la edición) antes que en cualquier otro idioma. (shrink)

La storiografia filosofica italiana nella seconda metà del XX secolo. La fase della ";normalizzazione"; e il circolo di filosofia e storia della filosofia.

El proyecto del ‘Darwinismo Formal’ de Alan Grafen propone una formulación matemática de la teoría de Darwin que pretende demostrar que la selección natural moldea los rasgos fenotípicos a través de la maximización de la eficacia. El proyecto de Grafen reposa sobre tres premisas: la selección natural es la única fuerza que moldea los fenotipos; la eficacia es la única medida de le evolución; y el diseño biológico surge como resultado de un proceso de optimización selectiva. En este trabajo argumentamos (...) que estas tres premisas limitan la aplicabilidad del modelo a los hechos evolutivos más simples. Esto se debe a que Grafen implícitamente presupone un concepto de eficacia que es a la vez causa y efecto de las novedades fenotípicas; lo que, por un lado, vacía la teoría de Darwin de poder explicativo y, por el otro, lleva a ignorar la potencial contribución de fuerzas evolutivas no selectivas en la configuración de la complejidad biológica. Para superar estos escollos del proyecto de del Darwinismo Formal - que son además comunes a todos los modelos formales adaptacionistas - proponemos sustituir el concepto causal de eficacia por el de robustez, definiendo así el diseño biológico como forma y función en lugar de como maximización de la eficacia. (shrink)